Glucagon-to-insulin ratio is pivotal for splanchnic regulation of FGF-21 in humans

• Autori principali: Jakob Schiøler Hansen (Autore), Jens Otto Clemmesen (Autore), Niels Henry Secher (Autore), Miriam Hoene (Autore), Andrea Drescher (Autore), Cora Weigert (Autore), Bente Klarlund Pedersen (Autore), Peter Plomgaard (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2015-08-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Background & aims: Fibroblast growth factor 21 (FGF-21) is a liver-derived metabolic regulator induced by energy deprivation. However, its regulation in humans is incompletely understood. We addressed the origin and regulation of FGF-21 secretion in humans. Methods: By determination of arterial-...