Cumulative Laxation Response with Methylnaltrexone: Implications for Hospitalized Patients with Advanced Illness and Opioid-Induced Constipation

• Autori principali: David Farchadi, MD, MS (Autore), Neal E. Slatkin, MD (Autore), Nancy Stambler, DrPH (Autore), Robert J. Israel, MD (Autore), Michael Matus, MD (Autore)
• Natura: Libro
• Pubblicazione: Elsevier, 2023-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Background: Opioid-induced constipation (OIC) may increase the risk of fecal impaction and mortality in patients with advanced illness. Methylnaltrexone (MNTX) is efficacious for OIC. Objective: The purpose of this analysis was to evaluate cumulative rescue-free laxation response with repeat MNTX do...