Tubulin/microtubules as novel clozapine targets

• Main Authors: Mizuki Hino (Author), Takeshi Kondo (Author), Yasuto Kunii (Author), Junya Matsumoto (Author), Akira Wada (Author), Shin‐ichi Niwa (Author), Mitsutoshi Setou (Author), Hirooki Yabe (Author)
• Format: Book
• Published: Wiley, 2022-03-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aim Clozapine is currently the only effective drug for treatment‐resistant schizophrenia; nonetheless, its pharmacological mechanism remains unclear, and its administration is limited because of severe adverse effects. By comparing the binding proteins of clozapine and its derivative olanza...