Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays

• मुख्य लेखकों: Chunlong Ma (लेखक), Haozhou Tan (लेखक), Juliana Choza (लेखक), Yuyin Wang (लेखक), Jun Wang (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2022-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

SARS-CoV-2 main protease (Mpro) is one of the most extensively exploited drug targets for COVID-19. Structurally disparate compounds have been reported as Mpro inhibitors, raising the question of their target specificity. To elucidate the target specificity and the cellular target engagement of the...