Validation and invalidation of SARS-CoV-2 main protease inhibitors using the Flip-GFP and Protease-Glo luciferase assays

• Главные авторы: Chunlong Ma (Автор), Haozhou Tan (Автор), Juliana Choza (Автор), Yuyin Wang (Автор), Jun Wang (Автор)
• Формат: ‌
• Опубликовано: Elsevier, 2022-04-01T00:00:00Z.
• Предметы: article
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SARS-CoV-2 main protease (Mpro) is one of the most extensively exploited drug targets for COVID-19. Structurally disparate compounds have been reported as Mpro inhibitors, raising the question of their target specificity. To elucidate the target specificity and the cellular target engagement of the...