Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study

• Asıl Yazarlar: Lea S Blaser (Yazar), Urs Duthaler (Yazar), Jamal Bouitbir (Yazar), Anne B Leuppi-Taegtmeyer (Yazar), Evangelia Liakoni (Yazar), Reto Dolf (Yazar), Michael Mayr (Yazar), Jürgen Drewe (Yazar), Stephan Krähenbühl (Yazar), Manuel Haschke (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Aim: The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated with the pharmacodynamic effect using urinary excretion of the prostacyclin m...