Comparative Effects of Metamizole (Dipyrone) and Naproxen on Renal Function and Prostacyclin Synthesis in Salt-Depleted Healthy Subjects - A Randomized Controlled Parallel Group Study

• Main Authors: Lea S Blaser (Author), Urs Duthaler (Author), Jamal Bouitbir (Author), Anne B Leuppi-Taegtmeyer (Author), Evangelia Liakoni (Author), Reto Dolf (Author), Michael Mayr (Author), Jürgen Drewe (Author), Stephan Krähenbühl (Author), Manuel Haschke (Author)
• Format: Book
• Published: Frontiers Media S.A., 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Aim: The objective was to investigate the effect of metamizole on renal function in healthy, salt-depleted volunteers. In addition, the pharmacokinetics of the four major metamizole metabolites were assessed and correlated with the pharmacodynamic effect using urinary excretion of the prostacyclin m...