Anti-Fn14 Antibody-Conjugated Nanoparticles Display Membrane TWEAK-Like Agonism

• Glavni autori: Ahmed Aido (Autor), Olena Zaitseva (Autor), Harald Wajant (Autor), Matej Buzgo (Autor), Aiva Simaite (Autor)
• Format: Knjiga
• Izdano: MDPI AG, 2021-07-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Conventional bivalent IgG antibodies targeting a subgroup of receptors of the TNF superfamily (TNFSF) including fibroblast growth factor-inducible 14 (anti-Fn14) typically display no or only very limited agonistic activity on their own and can only trigger receptor signaling by crosslinking or when...