Activation of AMPK Attenuated Cardiac Fibrosis by Inhibiting CDK2 via p21/p27 and miR-29 Family Pathways in Rats

• Main Authors: Hanping Qi (Author), Yan Liu (Author), Shuzhi Li (Author), Yunping Chen (Author), Lei Li (Author), Yonggang Cao (Author), Mingyao E (Author), Pilong Shi (Author), Chao Song (Author), Baiyan Li (Author), Hongli Sun (Author)
• Format: Book
• Published: Elsevier, 2017-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Cardiac fibrosis is pathological damage associated with nearly all forms of heart disease. AMP-activated protein kinase (AMPK) is an evolutionary conserved energy-sensing enzyme. Emerging evidences indicate that AMPK plays an important role in cardiac fibrosis and cell proliferation. However, less i...