Propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain

• Main Authors: Youwen Zhang (Author), Chang-uk Lim (Author), Vitali Sikirzhytski (Author), Asieh Naderi (Author), Ioulia Chatzistamou (Author), Hippokratis Kiaris (Author)
• Format: Book
• Published: The Company of Biologists, 2021-10-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The unfolded protein response (UPR) is involved in the pathogenesis of metabolic disorders, yet whether variations in the UPR among individuals influence the propensity for metabolic disease remains unexplored. Using outbred deer mice as a model, we show that the intensity of UPR in fibroblasts isol...