Propensity to endoplasmic reticulum stress in deer mouse fibroblasts predicts skin inflammation and body weight gain

• मुख्य लेखकों: Youwen Zhang (लेखक), Chang-uk Lim (लेखक), Vitali Sikirzhytski (लेखक), Asieh Naderi (लेखक), Ioulia Chatzistamou (लेखक), Hippokratis Kiaris (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: The Company of Biologists, 2021-10-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

The unfolded protein response (UPR) is involved in the pathogenesis of metabolic disorders, yet whether variations in the UPR among individuals influence the propensity for metabolic disease remains unexplored. Using outbred deer mice as a model, we show that the intensity of UPR in fibroblasts isol...