One Step Closer to Clinical Translation: Enhanced Tumor Targeting of [^99mTc]Tc-DB4 and [¹¹¹In]In-SG4 in Mice Treated with Entresto

• Main Authors: Panagiotis Kanellopoulos (Author), Aikaterini Kaloudi (Author), Maritina Rouchota (Author), George Loudos (Author), Marion de Jong (Author), Eric P. Krenning (Author), Berthold A. Nock (Author), Theodosia Maina (Author)
• Format: Book
• Published: MDPI AG, 2020-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Background: Peptide radioligands may serve as radionuclide carriers to tumor sites overexpressing their cognate receptor for diagnostic or therapeutic purposes. Treatment of mice with the neprilysin (NEP)-inhibitor phosphoramidon was previously shown to improve the metabolic stability and tumor upta...