One Step Closer to Clinical Translation: Enhanced Tumor Targeting of [^99mTc]Tc-DB4 and [¹¹¹In]In-SG4 in Mice Treated with Entresto

• Autores principales: Panagiotis Kanellopoulos (Autor), Aikaterini Kaloudi (Autor), Maritina Rouchota (Autor), George Loudos (Autor), Marion de Jong (Autor), Eric P. Krenning (Autor), Berthold A. Nock (Autor), Theodosia Maina (Autor)
• Formato: Libro
• Publicado: MDPI AG, 2020-11-01T00:00:00Z.
• Materias: article
• Acceso en línea: Connect to this object online.

Background: Peptide radioligands may serve as radionuclide carriers to tumor sites overexpressing their cognate receptor for diagnostic or therapeutic purposes. Treatment of mice with the neprilysin (NEP)-inhibitor phosphoramidon was previously shown to improve the metabolic stability and tumor upta...