One Step Closer to Clinical Translation: Enhanced Tumor Targeting of [^99mTc]Tc-DB4 and [¹¹¹In]In-SG4 in Mice Treated with Entresto

• Auteurs principaux: Panagiotis Kanellopoulos (Auteur), Aikaterini Kaloudi (Auteur), Maritina Rouchota (Auteur), George Loudos (Auteur), Marion de Jong (Auteur), Eric P. Krenning (Auteur), Berthold A. Nock (Auteur), Theodosia Maina (Auteur)
• Format: Livre
• Publié: MDPI AG, 2020-11-01T00:00:00Z.
• Sujets: article
• Accès en ligne: Connect to this object online.

Background: Peptide radioligands may serve as radionuclide carriers to tumor sites overexpressing their cognate receptor for diagnostic or therapeutic purposes. Treatment of mice with the neprilysin (NEP)-inhibitor phosphoramidon was previously shown to improve the metabolic stability and tumor upta...