Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity

• Главные авторы: Xiaoxia Xiao (Автор), Huiling Hu (Автор), Yadi Zhong (Автор), Yingjian Chen (Автор), Kaijia Tang (Автор), Zhisen Pan (Автор), Jiawen Huang (Автор), Xiaoying Yang (Автор), Qi Wang (Автор), Yong Gao (Автор)
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• Опубликовано: BMC, 2023-08-01T00:00:00Z.
• Предметы: article
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Abstract Background Microglia play a pivotal role in neuroinflammation, while obesity triggers hypothalamic microglia activation and inflammation. Sirt6 is an important regulator of energy metabolism in many peripheral tissues and hypothalamic anorexic neurons. However, the exact mechanism for micro...