Microglia Sirt6 modulates the transcriptional activity of NRF2 to ameliorate high-fat diet-induced obesity

• Main Authors: Xiaoxia Xiao (Author), Huiling Hu (Author), Yadi Zhong (Author), Yingjian Chen (Author), Kaijia Tang (Author), Zhisen Pan (Author), Jiawen Huang (Author), Xiaoying Yang (Author), Qi Wang (Author), Yong Gao (Author)
• Format: Book
• Published: BMC, 2023-08-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Background Microglia play a pivotal role in neuroinflammation, while obesity triggers hypothalamic microglia activation and inflammation. Sirt6 is an important regulator of energy metabolism in many peripheral tissues and hypothalamic anorexic neurons. However, the exact mechanism for micro...