Bexarotene Impairs Cognition and Produces Hypothyroidism in a Mouse Model of Down Syndrome and Alzheimer's Disease

• Main Authors: Verónica Vidal (Author), Alba Puente (Author), Susana García-Cerro (Author), María Teresa García Unzueta (Author), Noemí Rueda (Author), Javier Riancho (Author), Carmen Martínez-Cué (Author)
• Format: Bog
• Udgivet: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Fag: article
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All individuals with Down syndrome (DS) eventually develop Alzheimer's disease (AD) neuropathology, including neurodegeneration, increases in β-amyloid (Aβ) expression, and aggregation and neurofibrillary tangles, between the third and fourth decade of their lives. There is currently no effecti...