Bexarotene Impairs Cognition and Produces Hypothyroidism in a Mouse Model of Down Syndrome and Alzheimer's Disease

• Autors principals: Verónica Vidal (Autor), Alba Puente (Autor), Susana García-Cerro (Autor), María Teresa García Unzueta (Autor), Noemí Rueda (Autor), Javier Riancho (Autor), Carmen Martínez-Cué (Autor)
• Format: Llibre
• Publicat: Frontiers Media S.A., 2021-04-01T00:00:00Z.
• Matèries: article
• Accés en línia: Connect to this object online.

All individuals with Down syndrome (DS) eventually develop Alzheimer's disease (AD) neuropathology, including neurodegeneration, increases in β-amyloid (Aβ) expression, and aggregation and neurofibrillary tangles, between the third and fourth decade of their lives. There is currently no effecti...