S-Nitroso-L-Cysteine Stereoselectively Blunts the Deleterious Effects of Fentanyl on Breathing While Augmenting Antinociception in Freely-Moving Rats

• Egile Nagusiak: Paulina M. Getsy (Egilea), Santhosh M. Baby (Egilea), Ryan B. Gruber (Egilea), Benjamin Gaston (Egilea), Tristan H. J. Lewis (Egilea), Alan Grossfield (Egilea), James M. Seckler (Egilea), Yee-Hsee Hsieh (Egilea), James N. Bates (Egilea), Stephen J. Lewis (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Endogenous and exogenously administered S-nitrosothiols modulate the activities of central and peripheral systems that control breathing. We have unpublished data showing that the deleterious effects of morphine on arterial blood-gas chemistry (i.e., pH, pCO2, pO2, and sO2) and Alveolar-arterial gra...