S-Nitroso-L-Cysteine Stereoselectively Blunts the Deleterious Effects of Fentanyl on Breathing While Augmenting Antinociception in Freely-Moving Rats

• Main Authors: Paulina M. Getsy (Author), Santhosh M. Baby (Author), Ryan B. Gruber (Author), Benjamin Gaston (Author), Tristan H. J. Lewis (Author), Alan Grossfield (Author), James M. Seckler (Author), Yee-Hsee Hsieh (Author), James N. Bates (Author), Stephen J. Lewis (Author)
• Format: Book
• Published: Frontiers Media S.A., 2022-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endogenous and exogenously administered S-nitrosothiols modulate the activities of central and peripheral systems that control breathing. We have unpublished data showing that the deleterious effects of morphine on arterial blood-gas chemistry (i.e., pH, pCO2, pO2, and sO2) and Alveolar-arterial gra...