Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment

• Autori principali: Shimin An (Autore), Nimra Gilani (Autore), Yuan Huang (Autore), Adam Muncan (Autore), Youhua Zhang (Autore), Yi-Da Tang (Autore), A. Martin Gerdes (Autore), Kaie Ojamaa (Autore)
• Natura: Libro
• Pubblicazione: BMC, 2019-12-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

Abstract Pre-clinical animal studies have shown that triiodothyronine (T3) replacement therapy improves cardiac contractile function after myocardial infarction (MI). We hypothesized that T3 treatment could prevent adverse post-infarction cardiomyocyte remodeling by maintaining transverse-tubule (TT...