Adverse transverse-tubule remodeling in a rat model of heart failure is attenuated with low-dose triiodothyronine treatment

• Main Authors: Shimin An (Author), Nimra Gilani (Author), Yuan Huang (Author), Adam Muncan (Author), Youhua Zhang (Author), Yi-Da Tang (Author), A. Martin Gerdes (Author), Kaie Ojamaa (Author)
• Format: Book
• Published: BMC, 2019-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Pre-clinical animal studies have shown that triiodothyronine (T3) replacement therapy improves cardiac contractile function after myocardial infarction (MI). We hypothesized that T3 treatment could prevent adverse post-infarction cardiomyocyte remodeling by maintaining transverse-tubule (TT...