An inducible krasV12 transgenic zebrafish model for liver tumorigenesis and chemical drug screening

• Main Authors: Anh Tuan Nguyen (Author), Alexander Emelyanov (Author), Chor Hui Vivien Koh (Author), Jan M. Spitsbergen (Author), Serguei Parinov (Author), Zhiyuan Gong (Author)
• Format: Book
• Published: The Company of Biologists, 2012-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

SUMMARY Because Ras signaling is frequently activated by major hepatocellular carcinoma etiological factors, a transgenic zebrafish constitutively expressing the krasV12 oncogene in the liver was previously generated by our laboratory. Although this model depicted and uncovered the conservation betw...