Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

• Hauptverfasser: Chenxi Wang (Verfasst von), Xin Zhao (Verfasst von), Jingjing Jiang (Verfasst von), Mengqi Jia (Verfasst von), Wenqing Shi (Verfasst von), Zhenghua Wu (Verfasst von), Shiyu Feng (Verfasst von), Guorong Fan (Verfasst von), Yuefen Lou (Verfasst von)
• Format: Buch
• Veröffentlicht: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Schlagworte: article
• Online-Zugang: Connect to this object online.

BackgroundRhubarb, containing raw rhubarb (RR) and two processed products (steamed rhubarb, SR; carbonized rhubarb, CR), is commonly used in high-doses for the treatment of peptic ulcer, especially gastric ulcer (GU). However, their active ingredients, therapeutic targets, and potential mechanism re...