Integrated chemical analysis, metabolic profiling, network pharmacology, molecular docking and toxicity prediction to reveal the active ingredients and their safety of raw and prepared rhubarbs in the treatment of gastric ulcers

• Main Authors: Chenxi Wang (Author), Xin Zhao (Author), Jingjing Jiang (Author), Mengqi Jia (Author), Wenqing Shi (Author), Zhenghua Wu (Author), Shiyu Feng (Author), Guorong Fan (Author), Yuefen Lou (Author)
• Format: Book
• Published: Frontiers Media S.A., 2024-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BackgroundRhubarb, containing raw rhubarb (RR) and two processed products (steamed rhubarb, SR; carbonized rhubarb, CR), is commonly used in high-doses for the treatment of peptic ulcer, especially gastric ulcer (GU). However, their active ingredients, therapeutic targets, and potential mechanism re...