Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes

• Main Authors: Yunyun Zhan (Author), Anzhou Wang (Author), Yige Yu (Author), Jie Chen (Author), Xinhao Xu (Author), Jingjing Nie (Author), Jingjing Lin (Author)
• Format: Book
• Published: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Vortioxetine is a novel anti-major depression disorder drug with a high safety profile compared with other similar drugs. However, little research has been done on drug-drug interactions (DDI) about vortioxetine. In this paper, the inhibitory effect of vortioxetine on cytochrome P450 (CYP450) and th...