Inhibitory mechanism of vortioxetine on CYP450 enzymes in human and rat liver microsomes

• 主要な著者: Yunyun Zhan (著者), Anzhou Wang (著者), Yige Yu (著者), Jie Chen (著者), Xinhao Xu (著者), Jingjing Nie (著者), Jingjing Lin (著者)
• フォーマット: 図書
• 出版事項: Frontiers Media S.A., 2023-09-01T00:00:00Z.
• 主題: article
• オンライン･アクセス: Connect to this object online.

Vortioxetine is a novel anti-major depression disorder drug with a high safety profile compared with other similar drugs. However, little research has been done on drug-drug interactions (DDI) about vortioxetine. In this paper, the inhibitory effect of vortioxetine on cytochrome P450 (CYP450) and th...