Spanlastic-laden in situ gel as a promising approach for ocular delivery of Levofloxacin: In-vitro characterization, microbiological assessment, corneal permeability and in-vivo study

• Principais autores: Omnia Ahmed Agha (Autor), Germeen N.S. Girgis (Autor), Mohamed M.A. El-Sokkary (Autor), Osama Abd El-Azeem Soliman (Autor)
• Formato: Livro
• Publicado em: Elsevier, 2023-12-01T00:00:00Z.
• Assuntos: article
• Acesso em linha: Connect to this object online.

The objective of this study was to encapsulate the antibacterial drug levofloxacin hemihydrate (LF) into spanlastics (SLs) followed by incorporation into gelrite in situ gel to enhance its antibacterial activity and sustain ocular delivery. A combination of Span 60 as main vesicle component and Twee...