Early manifestation of depressive‐like behavior in transgenic mice that express dementia with Lewy body‐linked mutant β‐synuclein

• Hoofdauteurs: Masayo Fujita (Auteur), Yoko Hagino (Auteur), Yukio Takamatsu (Auteur), Yuka Shimizu (Auteur), Yoshiki Takamatsu (Auteur), Kazutaka Ikeda (Auteur), Makoto Hashimoto (Auteur)
• Formaat: Boek
• Gepubliceerd in: Wiley, 2018-06-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Abstract Aim We previously generated transgenic (Tg) mice that expressed P123H β‐synuclein (βS), a dementia with Lewy body‐linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor dysfunction, greater protein aggregation, and memory impa...