Early manifestation of depressive‐like behavior in transgenic mice that express dementia with Lewy body‐linked mutant β‐synuclein

• Main Authors: Masayo Fujita (Author), Yoko Hagino (Author), Yukio Takamatsu (Author), Yuka Shimizu (Author), Yoshiki Takamatsu (Author), Kazutaka Ikeda (Author), Makoto Hashimoto (Author)
• Format: Book
• Published: Wiley, 2018-06-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Abstract Aim We previously generated transgenic (Tg) mice that expressed P123H β‐synuclein (βS), a dementia with Lewy body‐linked mutant βS. Notably, these mice recapitulated neurodegenerative features of Lewy body disease, reflected by motor dysfunction, greater protein aggregation, and memory impa...