Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure.

• Main Authors: Michelle J Lin (Author), Austin M Haynes (Author), Amin Addetia (Author), Nicole A P Lieberman (Author), Quynh Phung (Author), Hong Xie (Author), Tien V Nguyen (Author), Barbara J Molini (Author), Sheila A Lukehart (Author), Lorenzo Giacani (Author), Alexander L Greninger (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2021-09-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been attributed to antigenic variation of its putative outer-membrane protein TprK. In TprK, amino acid diversity is confined to seven variable (V) regions, and generation of sequence diversity within the V regions occurs via...