Longitudinal TprK profiling of in vivo and in vitro-propagated Treponema pallidum subsp. pallidum reveals accumulation of antigenic variants in absence of immune pressure.

• Автори: Michelle J Lin (Автор), Austin M Haynes (Автор), Amin Addetia (Автор), Nicole A P Lieberman (Автор), Quynh Phung (Автор), Hong Xie (Автор), Tien V Nguyen (Автор), Barbara J Molini (Автор), Sheila A Lukehart (Автор), Lorenzo Giacani (Автор), Alexander L Greninger (Автор)
• Формат: Книга
• Опубліковано: Public Library of Science (PLoS), 2021-09-01T00:00:00Z.
• Предмети: article
• Онлайн доступ: Connect to this object online.

Immune evasion by Treponema pallidum subspecies pallidum (T. pallidum) has been attributed to antigenic variation of its putative outer-membrane protein TprK. In TprK, amino acid diversity is confined to seven variable (V) regions, and generation of sequence diversity within the V regions occurs via...