A kNGR Peptide-Tethered Lipid-Polymer Hybrid Nanocarrier-Based Synergistic Approach for Effective Tumor Therapy: Development, Characterization, Ex-Vivo, and In-Vivo Assessment

• Main Authors: Madhu Gupta (Author), Vikas Sharma (Author), Kalicharan Sharma (Author), Anoop Kumar (Author), Ajay Sharma (Author), Imran Kazmi (Author), Fahad A. Al-Abbasi (Author), Sami I. Alzarea (Author), Obaid Afzal (Author), Abdulmalik Saleh Alfawaz Altamimi (Author), Sachin Kumar Singh (Author), Gaurav Gupta (Author), Keshav Raj Paudel (Author), Philip M. Hansbro (Author), Kamal Dua (Author)
• Format: Book
• Published: MDPI AG, 2022-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The present study aims to design, develop and characterize kNGR (Asn-Gly-Arg) peptide-conjugated lipid-polymer-based nanoparticles for the target-specific delivery of anticancer bioactive(s), i.e., Paclitaxel (PTX). The kNGR-PEG-DSPE conjugate was synthesized and characterized by using spectral anal...