Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

• Asıl Yazarlar: Baoyuan Zhang (Yazar), Junfang Lyu (Yazar), Eun Ju Yang (Yazar), Yifan Liu (Yazar), Changjie Wu (Yazar), Lakhansing Pardeshi (Yazar), Kaeling Tan (Yazar), Qiang Chen (Yazar), Xiaoling Xu (Yazar), Chu-Xia Deng (Yazar), Joong Sup Shim (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Elsevier, 2020-04-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic target of DNA damaging agents. In this study,...