Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

• मुख्य लेखकों: Baoyuan Zhang (लेखक), Junfang Lyu (लेखक), Eun Ju Yang (लेखक), Yifan Liu (लेखक), Changjie Wu (लेखक), Lakhansing Pardeshi (लेखक), Kaeling Tan (लेखक), Qiang Chen (लेखक), Xiaoling Xu (लेखक), Chu-Xia Deng (लेखक), Joong Sup Shim (लेखक)
• स्वरूप: पुस्तक
• प्रकाशित: Elsevier, 2020-04-01T00:00:00Z.
• विषय: article
• ऑनलाइन पहुंच: Connect to this object online.

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic target of DNA damaging agents. In this study,...