Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

• Hoofdauteurs: Baoyuan Zhang (Auteur), Junfang Lyu (Auteur), Eun Ju Yang (Auteur), Yifan Liu (Auteur), Changjie Wu (Auteur), Lakhansing Pardeshi (Auteur), Kaeling Tan (Auteur), Qiang Chen (Auteur), Xiaoling Xu (Auteur), Chu-Xia Deng (Auteur), Joong Sup Shim (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2020-04-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic target of DNA damaging agents. In this study,...