Class I histone deacetylase inhibition is synthetic lethal with BRCA1 deficiency in breast cancer cells

• প্রধান লেখক: Baoyuan Zhang (লেখক), Junfang Lyu (লেখক), Eun Ju Yang (লেখক), Yifan Liu (লেখক), Changjie Wu (লেখক), Lakhansing Pardeshi (লেখক), Kaeling Tan (লেখক), Qiang Chen (লেখক), Xiaoling Xu (লেখক), Chu-Xia Deng (লেখক), Joong Sup Shim (লেখক)
• বিন্যাস: গ্রন্থ
• প্রকাশিত: Elsevier, 2020-04-01T00:00:00Z.
• বিষয়গুলি: article
• অনলাইন ব্যবহার করুন: Connect to this object online.

Breast cancer susceptibility gene 1 (BRCA1) is a tumor suppressor gene, which is frequently mutated in breast and ovarian cancers. BRCA1 plays a key role in the homologous recombination directed DNA repair, allowing its deficiency to act as a therapeutic target of DNA damaging agents. In this study,...