The Role of NOX2-Derived Reactive Oxygen Species in the Induction of Endothelin-Converting Enzyme-1 by Angiotensin II

• Main Authors: Michael Adu-Gyamfi (Author), Claudia Goettsch (Author), Julian Kamhieh-Milz (Author), Lei Chen (Author), Anna Maria Pfefferkorn (Author), Anja Hofmann (Author), Coy Brunssen (Author), Gregor Müller (Author), Thomas Walther (Author), Muhammad Imtiaz Ashraf (Author), Henning Morawietz (Author), Janusz Witowski (Author), Rusan Catar (Author)
• Format: Book
• Published: MDPI AG, 2024-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Endothelin-1 is a key regulator of vascular tone and blood pressure in health and disease. We have recently found that ET-1 production in human microvascular endothelial cells (HMECs) can be promoted by angiotensin II (Ang II) through a novel mechanism involving octamer-binding transcription factor-...