Screening and Evaluation of Potential Efflux Pump Inhibitors with a Seaweed Compound Diphenylmethane-Scaffold against Drug-Resistant <i>Escherichia coli</i>

• Main Authors: Wen-Jung Lu (Author), Yu-Wei Lian (Author), Chun-Ju Chang (Author), Hsuan-Ju Lin (Author), Chian-Yun Huang (Author), Pang-Hung Hsu (Author), Hong-Ting Lin (Author)
• Format: Book
• Published: MDPI AG, 2024-07-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Drug-resistant efflux pumps play a crucial role in bacterial antibiotic resistance. In this study, potential efflux pump inhibitors (EPIs) with a diphenylmethane scaffold were screened and evaluated against drug-resistant <i>Escherichia coli</i>. Twenty-four compounds were docked against...