Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo

• Main Authors: Melanie J. Mittenbühler (Author), Katarzyna Saedler (Author), Hendrik Nolte (Author), Lara Kern (Author), Jun Zhou (Author), Shu-Bing Qian (Author), Lydia Meder (Author), Roland T. Ullrich (Author), Jens C. Brüning (Author), F. Thomas Wunderlich (Author)
• Format: Book
• Published: Elsevier, 2020-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Single-nucleotide polymorphisms in the FTO gene encoding an m6Am and an m6A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of m6A modifications and its machinery, including FTO, to the development of several forms of cancers. However, the fun...