Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo

• Egile Nagusiak: Melanie J. Mittenbühler (Egilea), Katarzyna Saedler (Egilea), Hendrik Nolte (Egilea), Lara Kern (Egilea), Jun Zhou (Egilea), Shu-Bing Qian (Egilea), Lydia Meder (Egilea), Roland T. Ullrich (Egilea), Jens C. Brüning (Egilea), F. Thomas Wunderlich (Egilea)
• Formatua: Liburua
• Argitaratua: Elsevier, 2020-12-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Objective: Single-nucleotide polymorphisms in the FTO gene encoding an m6Am and an m6A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of m6A modifications and its machinery, including FTO, to the development of several forms of cancers. However, the fun...