Hepatic FTO is dispensable for the regulation of metabolism but counteracts HCC development in vivo

• Hoofdauteurs: Melanie J. Mittenbühler (Auteur), Katarzyna Saedler (Auteur), Hendrik Nolte (Auteur), Lara Kern (Auteur), Jun Zhou (Auteur), Shu-Bing Qian (Auteur), Lydia Meder (Auteur), Roland T. Ullrich (Auteur), Jens C. Brüning (Auteur), F. Thomas Wunderlich (Auteur)
• Formaat: Boek
• Gepubliceerd in: Elsevier, 2020-12-01T00:00:00Z.
• Onderwerpen: article
• Online toegang: Connect to this object online.

Objective: Single-nucleotide polymorphisms in the FTO gene encoding an m6Am and an m6A demethylase are associated with obesity. Moreover, recent studies have linked a dysregulation of m6A modifications and its machinery, including FTO, to the development of several forms of cancers. However, the fun...