Mendelian Randomisation Study of Childhood BMI and Early Menarche

• Autori principali: Hannah S. Mumby (Autore), Cathy E. Elks (Autore), Shengxu Li (Autore), Stephen J. Sharp (Autore), Kay-Tee Khaw (Autore), Robert N. Luben (Autore), Nicholas J. Wareham (Autore), Ruth J. F. Loos (Autore), Ken K. Ong (Autore)
• Natura: Libro
• Pubblicazione: Hindawi Limited, 2011-01-01T00:00:00Z.
• Soggetti: article
• Accesso online: Connect to this object online.

To infer the causal association between childhood BMI and age at menarche, we performed a mendelian randomisation analysis using twelve established "BMI-increasing" genetic variants as an instrumental variable (IV) for higher BMI. In 8,156 women of European descent from the EPIC-Norfolk co...