Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

• Үндсэн зохиолчид: Eva Baquedano (Зохиогч), Emma Burgos-Ramos (Зохиогч), Sandra Canelles (Зохиогч), Agueda González-Rodríguez (Зохиогч), Julie A. Chowen (Зохиогч), Jesús Argente (Зохиогч), Vicente Barrios (Зохиогч), Angela M. Valverde (Зохиогч), Laura M. Frago (Зохиогч)
• Формат: Ном
• Хэвлэсэн: The Company of Biologists, 2016-05-01T00:00:00Z.
• Нөхцлүүд: article
• Онлайн хандалт: Connect to this object online.

Insulin receptor substrate-2-deficient (IRS2−/−) mice are considered a good model to study the development of diabetes because IRS proteins mediate the pleiotropic effects of insulin-like growth factor-I (IGF-I) and insulin on metabolism, mitogenesis and cell survival. The hypothalamus might play a...