Increased oxidative stress and apoptosis in the hypothalamus of diabetic male mice in the insulin receptor substrate-2 knockout model

• Main Authors: Eva Baquedano (Author), Emma Burgos-Ramos (Author), Sandra Canelles (Author), Agueda González-Rodríguez (Author), Julie A. Chowen (Author), Jesús Argente (Author), Vicente Barrios (Author), Angela M. Valverde (Author), Laura M. Frago (Author)
• Format: Book
• Published: The Company of Biologists, 2016-05-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Insulin receptor substrate-2-deficient (IRS2−/−) mice are considered a good model to study the development of diabetes because IRS proteins mediate the pleiotropic effects of insulin-like growth factor-I (IGF-I) and insulin on metabolism, mitogenesis and cell survival. The hypothalamus might play a...