SC75741, A Novel c-Abl Inhibitor, Promotes the Clearance of TDP25 Aggregates via ATG5-Dependent Autophagy Pathway

• Egile Nagusiak: Dongheng Zhou (Egilea), Huanhuan Yan (Egilea), Shuying Yang (Egilea), Yuhong Zhang (Egilea), Xiaoyan Xu (Egilea), Xufeng Cen (Egilea), Kai Lei (Egilea), Hongguang Xia (Egilea)
• Formatua: Liburua
• Argitaratua: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Gaiak: article
• Sarrera elektronikoa: Connect to this object online.

Abnormal accumulation of TDP43-related mutant proteins in the cytoplasm causes amyotrophic lateral sclerosis (ALS). Herein, unbiased drug screening approaches showed that SC75741, a multi-target inhibitor, inhibited inflammation-induced aggregation by inhibiting NF-κB and also degraded already aggre...