SC75741, A Novel c-Abl Inhibitor, Promotes the Clearance of TDP25 Aggregates via ATG5-Dependent Autophagy Pathway

• Asıl Yazarlar: Dongheng Zhou (Yazar), Huanhuan Yan (Yazar), Shuying Yang (Yazar), Yuhong Zhang (Yazar), Xiaoyan Xu (Yazar), Xufeng Cen (Yazar), Kai Lei (Yazar), Hongguang Xia (Yazar)
• Materyal Türü: Kitap
• Baskı/Yayın Bilgisi: Frontiers Media S.A., 2021-10-01T00:00:00Z.
• Konular: article
• Online Erişim: Connect to this object online.

Abnormal accumulation of TDP43-related mutant proteins in the cytoplasm causes amyotrophic lateral sclerosis (ALS). Herein, unbiased drug screening approaches showed that SC75741, a multi-target inhibitor, inhibited inflammation-induced aggregation by inhibiting NF-κB and also degraded already aggre...