Recombinant human soluble thrombomodulin improved lipopolysaccharide/d-galactosamine-induced acute liver failure in mice

• Váldodahkkit: Wataru Osumi (Dahkki), Denan Jin (Dahkki), Yoshiro Imai (Dahkki), Keitaro Tashiro (Dahkki), Zhong-Lian Li (Dahkki), Yoshinori Otsuki (Dahkki), Kentaro Maemura (Dahkki), Koji Komeda (Dahkki), Fumitoshi Hirokawa (Dahkki), Michihiro Hayashi (Dahkki), Shinji Takai (Dahkki), Kazuhisa Uchiyama (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Elsevier, 2015-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

The effect of recombinant human soluble thrombomodulin (TM-α) on acute liver failure (ALF) is unclear, and we elucidated the effect of TM-α in lipopolysaccharide (LPS)/d-galactosamine (GalN)-induced ALF in mice. Placebo (saline) or TM-α (100 mg/kg) was administered 1 h after LPS/GalN administration....