Recombinant human soluble thrombomodulin improved lipopolysaccharide/d-galactosamine-induced acute liver failure in mice

• Main Authors: Wataru Osumi (Author), Denan Jin (Author), Yoshiro Imai (Author), Keitaro Tashiro (Author), Zhong-Lian Li (Author), Yoshinori Otsuki (Author), Kentaro Maemura (Author), Koji Komeda (Author), Fumitoshi Hirokawa (Author), Michihiro Hayashi (Author), Shinji Takai (Author), Kazuhisa Uchiyama (Author)
• Format: Book
• Published: Elsevier, 2015-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

The effect of recombinant human soluble thrombomodulin (TM-α) on acute liver failure (ALF) is unclear, and we elucidated the effect of TM-α in lipopolysaccharide (LPS)/d-galactosamine (GalN)-induced ALF in mice. Placebo (saline) or TM-α (100 mg/kg) was administered 1 h after LPS/GalN administration....