Critical role for adenosine receptor A2a in β-cell proliferation

• Main Authors: Nadja Schulz (Author), Ka-Cheuk Liu (Author), Jérémie Charbord (Author), Charlotte L. Mattsson (Author), Lingjie Tao (Author), Dominika Tworus (Author), Olov Andersson (Author)
• Format: Book
• Published: Elsevier, 2016-11-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Objective: Pharmacological activation of adenosine signaling has been shown to increase β-cell proliferation and thereby β-cell regeneration in zebrafish and rodent models of diabetes. However, whether adenosine has an endogenous role in regulating β-cell proliferation is unknown. The objective of t...