Rapid identification of highly potent human anti-GPCR antagonist monoclonal antibodies

• Main Authors: Martin J. Scott (Author), Amanda Jowett (Author), Martin Orecchia (Author), Peter Ertl (Author), Larissa Ouro-Gnao (Author), Julia Ticehurst (Author), David Gower (Author), John Yates (Author), Katie Poulton (Author), Carol Harris (Author), Michael J. Mullin (Author), Kathrine J. Smith (Author), Alan P. Lewis (Author), Nick Barton (Author), Michael L. Washburn (Author), Ruud de Wildt (Author)
• Format: Book
• Published: Taylor & Francis Group, 2020-01-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Complex cellular targets such as G protein-coupled receptors (GPCRs), ion channels, and other multi-transmembrane proteins represent a significant challenge for therapeutic antibody discovery, primarily because of poor stability of the target protein upon extraction from cell membranes. To assess wh...