Fast-tracking antibody maturation using a B cell-based display system

• Glavni autori: Hitomi Masuda (Autor), Atsushi Sawada (Autor), Shu-ichi Hashimoto (Autor), Kanako Tamai (Autor), Ke-Yi Lin (Autor), Naoto Harigai (Autor), Kohei Kurosawa (Autor), Kunihiro Ohta (Autor), Hidetaka Seo (Autor), Hiroshi Itou (Autor)
• Format: Knjiga
• Izdano: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Teme: article
• Online pristup: Connect to this object online.

Affinity maturation, an essential component of antibody engineering, is crucial for developing therapeutic antibodies. Cell display system coupled with somatic hypermutation (SHM) initiated by activation-induced cytidine deaminase (AID) is a commonly used technique for affinity maturation. AID intro...