Fast-tracking antibody maturation using a B cell-based display system

• Main Authors: Hitomi Masuda (Author), Atsushi Sawada (Author), Shu-ichi Hashimoto (Author), Kanako Tamai (Author), Ke-Yi Lin (Author), Naoto Harigai (Author), Kohei Kurosawa (Author), Kunihiro Ohta (Author), Hidetaka Seo (Author), Hiroshi Itou (Author)
• Format: Book
• Published: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

Affinity maturation, an essential component of antibody engineering, is crucial for developing therapeutic antibodies. Cell display system coupled with somatic hypermutation (SHM) initiated by activation-induced cytidine deaminase (AID) is a commonly used technique for affinity maturation. AID intro...