Fast-tracking antibody maturation using a B cell-based display system

• Váldodahkkit: Hitomi Masuda (Dahkki), Atsushi Sawada (Dahkki), Shu-ichi Hashimoto (Dahkki), Kanako Tamai (Dahkki), Ke-Yi Lin (Dahkki), Naoto Harigai (Dahkki), Kohei Kurosawa (Dahkki), Kunihiro Ohta (Dahkki), Hidetaka Seo (Dahkki), Hiroshi Itou (Dahkki)
• Materiálatiipa: Girji
• Almmustuhtton: Taylor & Francis Group, 2022-12-01T00:00:00Z.
• Fáttát: article
• Liŋkkat: Connect to this object online.

Affinity maturation, an essential component of antibody engineering, is crucial for developing therapeutic antibodies. Cell display system coupled with somatic hypermutation (SHM) initiated by activation-induced cytidine deaminase (AID) is a commonly used technique for affinity maturation. AID intro...