Vaccination of Gerbils with Bm-103 and Bm-RAL-2 Concurrently or as a Fusion Protein Confers Consistent and Improved Protection against Brugia malayi Infection.

• Main Authors: Sridhar Arumugam (Author), Junfei Wei (Author), Zhuyun Liu (Author), David Abraham (Author), Aaron Bell (Author), Maria Elena Bottazzi (Author), Peter J Hotez (Author), Bin Zhan (Author), Sara Lustigman (Author), Thomas R Klei (Author)
• Format: Book
• Published: Public Library of Science (PLoS), 2016-04-01T00:00:00Z.
• Subjects: article
• Online Access: Connect to this object online.

BACKGROUND:The Brugia malayi Bm-103 and Bm-RAL-2 proteins are orthologous to Onchocerca volvulus Ov-103 and Ov-RAL-2, and which were selected as the best candidates for the development of an O. volvulus vaccine. The B. malayi gerbil model was used to confirm the efficacy of these Ov vaccine candidat...